Advertorial
Luma Insider
Wellness Health 5 min read

Top 5 Probiotic Supplements in 2025

Author Jake L.

Jake L.

US Army Veteran • Tuesday 24 , 2025

Probiotics are critical for gut health, immune support, and overall digestive balance—and their popularity has exploded for a reason.

New research also shows they play a key role in weight management, brain function, and inflammation. But without high CFU counts and diverse strains, most products don’t survive digestion. That’s why we reviewed the most effective options and ranked the Top 5 Probiotic Supplements of 2025.

What to Look For in a Probiotic Supplement

  • High CFU Count

    You want at least 50 billion CFU per serving to make a real difference in your gut health.

  • Made in the USA & Third-Party Tested

    Always choose a supplement that’s made in the USA under strict quality standards. To ensure purity and safety, look for products that are independently tested by third-party labs.

  • Money-Back Guarantee

    Brands that offer a 90-day guarantee show confidence in their product. It gives you time to try the supplement and feel the difference—risk-free.

  • Fair and Hassle-Free Returns

    It should be easy to return a product if it doesn’t work for you. Avoid brands with unclear or restrictive return policies—look for those that make the process simple and honest.

What to Avoid

  • Weak CFU Count

    Many probiotics contain just a few strains or low CFU counts that don’t survive digestion. Look for multi-strain formulas with at least 50 billion CFU that are shelf-stable and gut-proven.

  • No 3rd-party testing

    Without third-party testing, you can’t be sure what’s really in the bottle. Choose supplements that are tested for purity and potency.

  • No refund policy

    If there’s no money-back guarantee, think twice. Reliable brands make it easy to return a product if it doesn’t work for you.

  • The Cheapest Option

    Cheaper products often mean weak doses, fillers, or poor sourcing. For something you take daily, it’s worth paying for quality.

#1 choice

Subscribe & Save Up to 40%

Card Product Image - Probiotic
$44.99 $23.99 /Per Bottle
Shop Now
  • FREE shipping
  • 90-Day Guarantee
  • Easy cancel, skip, or pause
Ships today

within 12hr 00mins 00sec if ordered now

Top 5 Probiotic Supplements in 2025

1. Luma Nutrition Probiotic

by Luma Nutrition

Product image
A+ Overall Grade *
Product image
Overall Grade * A+
REVIEW SCORE 4.9 EXCELLENT
BASED ON 1,477 REVIEWS
  • Benefit icon 1
    American Made

    Made in the USA in an FDA-regulated facility. Luma Nutrition adheres to Good Manufacturing Practices (GMPs).

  • Benefit icon 2
    Contains Prebiotics

    These are essential to help feed the probiotics and give them the best opportunity to thrive in your gut biome. 

  • Benefit icon 3
    3rd Party Tested for Potency & Safety

    An independent lab tests all Luma Nutrition products to make sure they’re potent and free from harmful substances.

  • Benefit icon 4
    90 Day Return Policy

    Luma Nutrition offers a fair, 90-day, risk-free, money-back guarantee. If you don't like the product, simply return it for a refund.

  • Made in
    the USA
  • 90 Day Money Back Guarantee
  • 3rd Party Tested For Safety

Pros

  • Contains quality ingredients
  • Positive verified reviews
  • Subscribe & Save options

Cons

  • Sometimes runs out of stock
  • Only available online
Overall

Our Luma Nutrition Probiotic earns its spot with a hefty 50 billion CFU per serving drawn from premium strains—no under-dosed blends here . Produced in an FDA-regulated U.S. facility by a veteran-led team and third-party tested for purity , it’s safeguarded by our 90-day money-back guarantee, letting you tackle gut health, immunity, and bloating risk-free .

  • Sell Out Risk: High
  • FREE shipping
  • 90-Day Guarantee
*Scores and results are based on our ranking system and do no necessarily reflect typical results from the use of these products. Please visit product websites for more information.

2. Luma Nutrition Women’s Probiotic

by Luma Nutrition

Product image
A Overall Grade *

Pros

  • Contains a powerful dose of 50 billion CFUs per serving
  • Contains probiotic strain specifically selected for their benefit to women and feminine health
  • Good balance between quality and price
  • Vegan, Non GMO, Gluten Free
  • Made in the USA
  • 90 Day, risk free, money back guarantee

Cons

  • High demand for this product means it can sometimes be out of stock

OVERALL

A close second on the rankings is Luma Nutrition’s Women’s Probiotic. This is ranked #2 because it is specifically targeted only towards women, but otherwise is a great option.

What makes this different than the regular probiotic, is that there are specific strains of probiotics that have been shown to have special benefits for feminine health.

This product uses a powerful dose 50 billion CFUs per serving. Their formula also contains prebiotics, which is vital.

Luma Nutrition has a few different special offers available that give customers a big discount.

Finally, they offer a fair, 90-day, risk-free, money-back guarantee. Most companies won’t do this, which shows how much they stand behind their products. Overall, LumaNutrition is our top pick.

*Scores and results are based on the our ranking system and do not necessarily reflect typical results from the use of these products.

Please visit product websites for more information.

View Product Details

3. Align Probiotic

by Align

Product image
B Overall Grade *

Pros

  • Great quality
  • Good brand reputation

Cons

  • Unclear how many CFUs of probiotics are included

OVERALL

Number three on our list is Align Probiotic.

This is another brand with a very good reputation for quality. The issue with this product is that the dosage is a bit unclear. It is not clear how many CFUs are included in the formulation.

This one was also the more expensive products we analyzed.

Overall, Align Probiotic is a good brand, and could be an option if you are willing to spend top dollar. But it falls short when compared to other products on the list.

*Scores and results are based on the our ranking system and do not necessarily reflect typical results from the use of these products.

Please visit product websites for more information.

View Product Details

4. Raw Probiotics

by Garden of Life

Product image
B- Overall Grade *

Pros

  • Good brand reputation
  • Strong dosage

Cons

  • Fairly expensive

OVERALL

Number four on our list is Garden of Life Raw Probiotics.

This brand does have a good reputation, and the formulation is pretty interesting. The biggest problem is the expensive pricing.

In summary, Garden of Life does use quality ingredients, but it ranks lower on value.

*Scores and results are based on the our ranking system and do not necessarily reflect typical results from the use of these products.

Please visit product websites for more information.

View Product Details

5. Dr. Ohhira’s Probiotics

by Dr. Ohhira

Product image
B- Overall Grade *

Pros

  • Interesting formula that contains food based probiotics

Cons

  • Dosage and CFUs are unclear

OVERALL

Number five on our list is Dr. Ohhira’s Probiotics.

This product has an interesting formula that contains food based probiotics and prebiotics.

The main issue is that the CFUs and strength of the dosage is a bit unclear.

In conclusion, Dr. Ohhira’s Probiotics is a good choice based on the reputation and interesting ingredients, but we have to rank it lower based on the unclear dosage. 

*Scores and results are based on the our ranking system and do not necessarily reflect typical results from the use of these products.

Please visit product websites for more information.

View Product Details

Top-Rated Probiotic Supplement

Formulated with 50 billion CFU across 11 strains plus prebiotic fiber, this probiotic nurtures a balanced microbiome and digestive comfort—all with Luma’s 90-day safety net.

#1 Choice Product Image
Luma’s 50 Billion CFU Advanced Probiotic
  • Restores gut flora & eases bloating
  • Supports immune defenses & nutrient absorption
  • Delayed-release capsules survive stomach acid
  • Made in USA & 3rd party tested for purity and quality
  • Sell Out Risk: High
  • FREE shipping
  • 90-Day Guarantee
Banner Image Banner Image

What is a Probiotic Formula?

What is this product?

Probiotics are live, beneficial bacteria—often Lactobacillus and Bifidobacterium species—that you ingest to seed or “re-seed” your gut microbiome. A balanced microbiome influences digestion, immunity, and even neurotransmitter production.Taking a broad-spectrum, high-CFU probiotic can help:
• Restore healthy digestion and reduce bloating
• Strengthen immune defenses
• Improve nutrient absorption and gut-brain communication